DMPK & ADMET Chemistry

In Vivo Pharmacokinetics

Rapid Turnaround

Five working days

In Vivo Dosing

Bolus IV
IV infusion
Oral
Intra-duodenal

Biological Matrices

Blood/plasma/urine/feces
Bile
Cerebrospinal fluid
Tissues or tumor specimens

Service Offerings

Bioavailability
Biliary vs. urinary excretion
Dose ranging and proportionality
Bioequivalence

Deliverables

Sample concentrations
PK parameters

Species

Rodent
Canine
Non-human primate

In Vitro ADMET Profiling

In Vitro Metabolism

Study Types

Protein binding
Stability in different pH buffers, plasma and artificial intestinal fluid
Permeability assay

PAMPA
Caco-2
MDR1 and MDCK

Cell proliferation and cytotoxicity
Metabolic stability and biotransformation

Test systems (microsomes, hepatocytes, S9, recombinant enzymes)
Species (rodent, guinea pig, rabbit, canine, nonhuman primate, human)

Drug-drug-interaction (in vitro and in vivo)

CYP inhibition
CYP induction
CYP phenotyping

Metabolite ID and profiling
Mass balance and drug disposition