Discovery Biology

Pharmacology at WuXi AppTec offers extensive in vivo models in many therapeutic areas to provide high quality services to support drug development including in vivo proof of concept, efficacy screening, target validation, target engagement and mechanism of action studies.

People: Pharmacology is led by returnees with many years of Western pharmaceutical experience, involving in drug development taking chemical entities from basic research to regulatory approval of current medications. Together with domestic trained talents, our teams have a record of providing excellent services to our customers.

Facility: A world class, AAALAC accredited, 33,000 square-foot pharmacology facility in the Shanghai provides laboratories to support metabolic diseases, pain, inflammation and neuroscience projects. The facility also includes ample barrier area for oncology studies and Biosafety Level 2 laboratories for infectious diseases to provide additional in vivo models and services.

Therapeutic Areas: Centers of Excellence are established in the area of pain, inflammation, diabetes and obesity. Experienced leaders in oncology, infectious diseases and neuroscience provide services and input in their specialized areas. Pharmacology aims to provide efficient, cost-effective and value-added services and will expand to additional areas in the future.

Pain and Inflammation Models

Acute inflammatory pain

  • Formalin paw
  • Carrageenan paw

Chronic inflammatory pain

  • Freund’s complete adjuvant

Acute nociception

  • Tail flick
  • Hot plate

Neuropathic pain

  • Chung model
  • Bennett model
  • Chemotherapy agent-induced pain

Visceral pain

  • Acetic acid writhing

Inflammation

  • Carrageenan/CFA paw edema
  • Adjuvant-induced arthristis
  • Monoiodoactetat-induced arthritis
  • Collagen-induced arthritis

Diabetes and Obesity Models

Obesity

  • Diet-induced obese mouse

Diabetes

  • Streptozotoxin-induced diabetes
  • Type 2 diabetes
    • GK rat
    • db/db and ob/ob mouse

Mouse/rat oral glucose tolerance test with concurrent insulin measurement

Mouse/rat insulin tolerance test

Rat glucagon challenge

Oncology Xenograft Models

Over 30 cancer cell lines covering most cancer types have been validated for tumor growth and compound effects in athymic mice

  • Lung: A549, H460, H69, NCI-H358, NCI-H292, NCI-H322
  • Colorectal: HT29, Colo205, HT29, HCT-116, SW620, DLD-1
  • Brain (GBM): U87
  • Breast: MDA-MB-231, MCF-7, MDA-MB-435S
  • Liver: Hep G2
  • Pancreas: Mia-pa-ca-2, Bx-PC3, PANC-1
  • Bladder: T24/83
  • Stomach: KATO-III
  • Head and Neck: Cal27, A673
  • Hematopoietic: MV4-11, K562, Daudi, MOLT-4
  • Prostate: PC3
  • Melanoma: A375
  • Ovarian: A2780, SK-OV-3
  • Sarcoma: HT108

More than 80 additional cancer cell lines available to be validated in the xenograft models

Cardiovascular Disease Models

  • Telemetrized SHR (spontaneously hypertensive rats)
  • Diuresis
  • Acute heart failure
  • Anesthetized dog for acute cardiovascular toxicity

CNS Models

  • Irwin test
  • FOB (functional observational battery)
  • Neurology models
  • Psychiatry models

Custom Built Models

Pharmacology also provides service to custom build models in consultation with our customers

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