Discovery Biology
Pharmacology at WuXi AppTec offers extensive in vivo models in many therapeutic areas to provide high quality services to support drug development including in vivo proof of concept, efficacy screening, target validation, target engagement and mechanism of action studies.
People: Pharmacology is led by returnees with many years of Western pharmaceutical experience, involving in drug development taking chemical entities from basic research to regulatory approval of current medications. Together with domestic trained talents, our teams have a record of providing excellent services to our customers.
Facility: A world class, AAALAC accredited, 33,000 square-foot pharmacology facility in the Shanghai provides laboratories to support metabolic diseases, pain, inflammation and neuroscience projects. The facility also includes ample barrier area for oncology studies and Biosafety Level 2 laboratories for infectious diseases to provide additional in vivo models and services.
Therapeutic Areas: Centers of Excellence are established in the area of pain, inflammation, diabetes and obesity. Experienced leaders in oncology, infectious diseases and neuroscience provide services and input in their specialized areas. Pharmacology aims to provide efficient, cost-effective and value-added services and will expand to additional areas in the future.
Pain and Inflammation Models
Acute inflammatory pain
- Formalin paw
- Carrageenan paw
Chronic inflammatory pain
- Freund’s complete adjuvant
Acute nociception
- Tail flick
- Hot plate
Neuropathic pain
- Chung model
- Bennett model
- Chemotherapy agent-induced pain
Visceral pain
- Acetic acid writhing
Inflammation
- Carrageenan/CFA paw edema
- Adjuvant-induced arthristis
- Monoiodoactetat-induced arthritis
- Collagen-induced arthritis
Diabetes and Obesity Models
Obesity
- Diet-induced obese mouse
Diabetes
- Streptozotoxin-induced diabetes
- Type 2 diabetes
- GK rat
- db/db and ob/ob mouse
Mouse/rat oral glucose tolerance test with concurrent insulin measurement
Mouse/rat insulin tolerance test
Rat glucagon challenge
Oncology Xenograft Models
Over 30 cancer cell lines covering most cancer types have been validated for tumor growth and compound effects in athymic mice
- Lung: A549, H460, H69, NCI-H358, NCI-H292, NCI-H322
- Colorectal: HT29, Colo205, HT29, HCT-116, SW620, DLD-1
- Brain (GBM): U87
- Breast: MDA-MB-231, MCF-7, MDA-MB-435S
- Liver: Hep G2
- Pancreas: Mia-pa-ca-2, Bx-PC3, PANC-1
- Bladder: T24/83
- Stomach: KATO-III
- Head and Neck: Cal27, A673
- Hematopoietic: MV4-11, K562, Daudi, MOLT-4
- Prostate: PC3
- Melanoma: A375
- Ovarian: A2780, SK-OV-3
- Sarcoma: HT108
More than 80 additional cancer cell lines available to be validated in the xenograft models
Cardiovascular Disease Models
- Telemetrized SHR (spontaneously hypertensive rats)
- Diuresis
- Acute heart failure
- Anesthetized dog for acute cardiovascular toxicity
CNS Models
- Irwin test
- FOB (functional observational battery)
- Neurology models
- Psychiatry models
Custom Built Models
Pharmacology also provides service to custom build models in consultation with our customers